I remember my reaction back when the lineup for the upcoming Suicide Squad movie was announced last year being a shake of the head and a sensible chuckle. James Gunn really would pick characters like Weasel, Ratcatcher 2, and Polka-Dot Man for a major big budget comic book movie. The other person I can think of right off the top of my head who would make similar choices is Ryan Reynolds.
But honestly? I dig it. Like Marvel, DC Comics has a deep roster of characters that they draw from for their movies and TV shows, so they don't have to rely on more like "marquee" characters such as Superman and Batman for example. It'll be interesting to see where things lead if The Suicide Squad is a big hit. Maybe we'll see more lesser knowns be pulled out of obscurity and given the spotlight.